Atherosclerosis is a complicated and multi-faceted process of disease where endothelial dysfunction, formation of foam cell, retention of lipoprotein, oxidative stress, and inflammation cause plaque formation and progression, aggregation of platelet, plaque rupture, and formation of thrombus. It is a known risk factor for atherosclerosis and cardiovascular diseases. polium extract could improve endothelial dysfunction by ameliorating the vasoreactivity and regulating eNOS and VCAM-1 gene expressions as well in STZ-induced diabetic rats' aorta.ĭiabetes is a metabolic disorder with the known main characteristic of hyperglycemia and glucose intolerance due to insulin deficiency, tissue resistance to insulin or both. polium and metformin significantly increased eNOS expression, while it decreased VCAM-1 expressions in aortic tissue of diabetic rats.
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Real-time polymerase chain reaction (PCR) analysis showed that T.
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polium extract significantly improved vasorelaxant response of aortic rings to acetylcholine (Ach). It was also observed that metformin and T. polium extract was found to significantly reduce serum glucose level. polium extract, daily by gavage for 6 weeks. polium groups were given 100, 200, and 400 mg/kg T. The control and diabetic groups were given normal saline metformin group was given 300 mg/kg metformin and T. Male Wistar rats were randomly divided into six groups: control, diabetic, metformin, and three groups of T. polium hydroalcoholic extract on the vasoreactivity and endothelial nitric oxide synthase (eNOS) and vascular cell adhesion molecule (VCAM)-1 genes expression as well in streptozotocin (STZ)-induced diabetic rat aorta.
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As a result of this, the present study was conducted to evaluate the impacts of T. is traditionally used for the production of antidiabetic herbal medicine. Endothelial dysfunction is the major cause of vascular complications in diabetes.